Using Spam Assassin correctly will
help to eliminate a sizeable portion of your spam
emails.
The trick is to configure Spam Assassin in such a way as to
have all your spam deleted - as opposed to saving it in the spam box.
The first step is to log into your cPanel and click on the
MAIL icon.

You should now be
looking at the Mail sub-menu. Click on the link which
say's "Spam Assassin"

This will bring you into the
Spam Assassin
area.
Next - click on the
"Enable Spam Assassin" button.

Once Spam Assassin is
enabled, click on the "Go Back" link.

You'll note that Spam
Assassin now shows as being enabled.
Now - click on the
"click here" link as shown below:

You have just set up
Spam Assassin and configured it to immediately delete
any emails which it has flagged as spam.